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Considering the fact that Pirfenidone is metabolised from the CYP1A2 enzyme pathway, any drug which inhibits this enzyme is likely to precipitate the toxicity of pirfenidone: concomitant therapy is always to be avoided.lonapegsomatropin will reduce the level or influence of pirfenidone by impacting hepatic enzyme CYP1A2 metabolism.Use of solid CYP1